1PWQ
Crystal structure of Anthrax Lethal Factor complexed with Thioacetyl-Tyr-Pro-Met-Amide, a metal-chelating peptidyl small molecule inhibitor
Summary for 1PWQ
Entry DOI | 10.2210/pdb1pwq/pdb |
Related | 1PWP |
Descriptor | Lethal factor, ZINC ION, N-(SULFANYLACETYL)TYROSYLPROLYLMETHIONINAMIDE (3 entities in total) |
Functional Keywords | anthrax toxin, lethal factor, metal-chelator, small molecule peptidic inhibitor, hydrolase |
Biological source | Bacillus anthracis |
Cellular location | Secreted: P15917 |
Total number of polymer chains | 2 |
Total formula weight | 181809.68 |
Authors | Wong, T.Y.,Schwarzenbacher, R.,Liddington, R.C. (deposition date: 2003-07-02, release date: 2004-01-13, Last modification date: 2023-08-16) |
Primary citation | Turk, B.E.,Wong, T.Y.,Schwarzenbacher, R.,Jarrell, E.T.,Leppla, S.H.,Collier, R.J.,Liddington, R.C.,Cantley, L.C. The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor. Nat.Struct.Mol.Biol., 11:60-66, 2004 Cited by PubMed: 14718924DOI: 10.1038/nsmb708 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.52 Å) |
Structure validation
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