1PWL

Crystal structure of human Aldose Reductase complexed with NADP and Minalrestat

1PWL の概要

• エントリーDOI: 10.2210/pdb1pwl/pdb
• 関連するPDBエントリー: 1PWM
• 分子名称: aldose reductase, 2[4-BROMO-2-FLUOROPHENYL)METHYL]-6-FLUOROSPIRO[ISOQUINOLINE-4-(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
• 機能のキーワード: aldose reductase, atomic resolution, ternary complex, inhibitor binding, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P15121
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37090.95

構造登録者

El-Kabbani, O.,Darmanin, C.,Schneider, T.R.,Hazemann, I.,Ruiz, F.,Oka, M.,Joachimiak, A.,Schulze-Briese, C.,Tomizaki, T.,Mitschler, A.,Podjarny, A. (登録日: 2003-07-02, 公開日: 2004-02-24, 最終更新日: 2024-04-03)

• 主引用文献: El-Kabbani, O.,Darmanin, C.,Schneider, T.R.,Hazemann, I.,Ruiz, F.,Oka, M.,Joachimiak, A.,Schulze-Briese, C.,Tomizaki, T.,Mitschler, A.,Podjarny, A.; Ultrahigh resolution drug design. II. Atomic resolution structures of human aldose reductase holoenzyme complexed with Fidarestat and Minalrestat: implications for the binding of cyclic imide inhibitors; PROTEINS, 55:805-813, 2004; PubMed: 15146479; DOI: 10.1002/prot.20001

実験手法

X-RAY DIFFRACTION (1.1 Å)