1PVH

Crystal structure of leukemia inhibitory factor in complex with gp130

Summary for 1PVH

Entry DOI	10.2210/pdb1pvh/pdb
Descriptor	Interleukin-6 receptor beta chain, Leukemia inhibitory factor, IODIDE ION, ... (4 entities in total)
Functional Keywords	cytokine, receptor, signaling, beta sheet, four helix bundle, signaling protein-cytokine complex, signaling protein/cytokine
Biological source	Homo sapiens (human) More
Cellular location	Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P40189 Secreted: P15018
Total number of polymer chains	4
Total formula weight	83690.83
Authors	Boulanger, M.J.,Bankovich, A.J.,Kortemme, T.,Baker, D.,Garcia, K.C. (deposition date: 2003-06-27, release date: 2003-10-14, Last modification date: 2023-08-16)
Primary citation	Boulanger, M.J.,Bankovich, A.J.,Kortemme, T.,Baker, D.,Garcia, K.C. Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130. Mol.Cell, 12:577-589, 2003 Cited by PubMed: 14527405 DOI: 10.1016/S1097-2765(03)00365-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation