1PVH

Crystal structure of leukemia inhibitory factor in complex with gp130

1PVH の概要

• エントリーDOI: 10.2210/pdb1pvh/pdb
• 分子名称: Interleukin-6 receptor beta chain, Leukemia inhibitory factor, IODIDE ION, ... (4 entities in total)
• 機能のキーワード: cytokine, receptor, signaling, beta sheet, four helix bundle, signaling protein-cytokine complex, signaling protein/cytokine
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P40189; Secreted: P15018
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 83690.83

構造登録者

Boulanger, M.J.,Bankovich, A.J.,Kortemme, T.,Baker, D.,Garcia, K.C. (登録日: 2003-06-27, 公開日: 2003-10-14, 最終更新日: 2023-08-16)

• 主引用文献: Boulanger, M.J.,Bankovich, A.J.,Kortemme, T.,Baker, D.,Garcia, K.C.; Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130.; Mol.Cell, 12:577-589, 2003; PubMed: 14527405; DOI: 10.1016/S1097-2765(03)00365-4

実験手法

X-RAY DIFFRACTION (2.5 Å)