1PSR

HUMAN PSORIASIN (S100A7)

Summary for 1PSR

• Entry DOI: 10.2210/pdb1psr/pdb
• Descriptor: PSORIASIN, HOLMIUM ATOM (3 entities in total)
• Functional Keywords: ef-hand protein, mad phasing, psoriasis, s100 protein family
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P31151
• Total number of polymer chains: 2
• Total formula weight: 23017.43

Authors

Brodersen, D.E.,Etzerodt, M.,Madsen, P.,Celis, J.,Thoegersen, H.C.,Nyborg, J.,Kjeldgaard, M. (deposition date: 1997-11-27, release date: 1999-01-13, Last modification date: 2024-11-13)

Primary citation

Brodersen, D.E.,Etzerodt, M.,Madsen, P.,Celis, J.E.,Thogersen, H.C.,Nyborg, J.,Kjeldgaard, M.
EF-hands at atomic resolution: the structure of human psoriasin (S100A7) solved by MAD phasing.
Structure, 6:477-489, 1998

PubMed Abstract: The S100 family consists of small acidic proteins, belonging to the EF-hand class of calcium-binding proteins. They are primarily regulatory proteins, involved in cell growth, cell structure regulation and signal transduction. Psoriasin (S100A7) is an 11.7 kDa protein that is highly upregulated in the epidermis of patients suffering from the chronic skin disease psoriasis. Although its exact function is not known, psoriasin is believed to participate in the biochemical response which follows transient changes in the cellular Ca2+ concentration.

PubMed: 9562557
DOI: 10.1016/S0969-2126(98)00049-5

Experimental method

X-RAY DIFFRACTION (1.05 Å)