1PSR

HUMAN PSORIASIN (S100A7)

1PSR の概要

• エントリーDOI: 10.2210/pdb1psr/pdb
• 分子名称: PSORIASIN, HOLMIUM ATOM (3 entities in total)
• 機能のキーワード: ef-hand protein, mad phasing, psoriasis, s100 protein family
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P31151
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 23017.43

構造登録者

Brodersen, D.E.,Etzerodt, M.,Madsen, P.,Celis, J.,Thoegersen, H.C.,Nyborg, J.,Kjeldgaard, M. (登録日: 1997-11-27, 公開日: 1999-01-13, 最終更新日: 2024-11-13)

主引用文献

Brodersen, D.E.,Etzerodt, M.,Madsen, P.,Celis, J.E.,Thogersen, H.C.,Nyborg, J.,Kjeldgaard, M.
EF-hands at atomic resolution: the structure of human psoriasin (S100A7) solved by MAD phasing.
Structure, 6:477-489, 1998

PubMed Abstract: The S100 family consists of small acidic proteins, belonging to the EF-hand class of calcium-binding proteins. They are primarily regulatory proteins, involved in cell growth, cell structure regulation and signal transduction. Psoriasin (S100A7) is an 11.7 kDa protein that is highly upregulated in the epidermis of patients suffering from the chronic skin disease psoriasis. Although its exact function is not known, psoriasin is believed to participate in the biochemical response which follows transient changes in the cellular Ca2+ concentration.

PubMed: 9562557
DOI: 10.1016/S0969-2126(98)00049-5

実験手法

X-RAY DIFFRACTION (1.05 Å)