1PQC

HUMAN LXR BETA HORMONE RECEPTOR COMPLEXED WITH T0901317

1PQC の概要

• エントリーDOI: 10.2210/pdb1pqc/pdb
• 関連するPDBエントリー: 1pq6 1pq9
• 分子名称: Oxysterols receptor LXR-beta, N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE (3 entities in total)
• 機能のキーワード: lxrb+t0901317, transcription regulation
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus (Potential): P55055
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 118154.46

構造登録者

Farnegardh, M.,Bonn, T.,Sun, S.,Ljunggren, J.,Ahola, H.,Wilhelmsson, A.,Gustafsson, J.-A.,Carlquist, M. (登録日: 2003-06-18, 公開日: 2003-09-09, 最終更新日: 2024-04-03)

主引用文献

Farnegardh, M.,Bonn, T.,Sun, S.,Ljunggren, J.,Ahola, H.,Wilhelmsson, A.,Gustafsson, J.-A.,Carlquist, M.
The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands.
J.Biol.Chem., 278:38821-38828, 2003

PubMed Abstract: The structures of the liver X receptor LXRbeta (NR1H2) have been determined in complexes with two synthetic ligands, T0901317 and GW3965, to 2.1 and 2.4 A, respectively. Together with its isoform LXRalpha (NR1H3) it regulates target genes involved in metabolism and transport of cholesterol and fatty acids. The two LXRbeta structures reveal a flexible ligand-binding pocket that can adjust to accommodate fundamentally different ligands. The ligand-binding pocket is hydrophobic but with polar or charged residues at the two ends of the cavity. T0901317 takes advantage of this by binding to His-435 close to H12 while GW3965 orients itself with its charged group in the opposite direction. Both ligands induce a fixed "agonist conformation" of helix H12 (also called the AF-2 domain), resulting in a transcriptionally active receptor.

PubMed: 12819202
DOI: 10.1074/jbc.M304842200

実験手法

X-RAY DIFFRACTION (2.8 Å)