1PO6

Crystal Structure of UP1 Complexed With d(TAGG(6MI)TTAGGG): A Human Telomeric Repeat Containing 6-methyl-8-(2-deoxy-beta-ribofuranosyl)isoxanthopteridine (6MI)

1PO6 の概要

• エントリーDOI: 10.2210/pdb1po6/pdb
• 分子名称: 5'-D(*T*AP*GP*GP*(6MI)P*TP*TP*AP*GP*GP*G)-3', Heterogeneous nuclear ribonucleoprotein A1 (3 entities in total)
• 機能のキーワード: protein-dna complex, up1, human telomeric repeat, htr, tr2-6f, rrm, rna recognition motif, 6mi, 6-methyl-8-(2-deoxy-beta-ribofuranosyl)isoxanthopteridine, hnrnp a1, rna binding protein-dna complex, rna binding protein/dna
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: P09651
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 24392.83

構造登録者

Myers, J.C.,Moore, S.A.,Shamoo, Y. (登録日: 2003-06-13, 公開日: 2003-11-11, 最終更新日: 2023-08-16)

• 主引用文献: Myers, J.C.,Moore, S.A.,Shamoo, Y.; Structure-based incorporation of 6-methyl-8-(2-deoxy-beta-ribofuranosyl)isoxanthopteridine into the human telomeric repeat DNA as a probe for UP1 binding and destabilization of G-tetrad structures; J.BIOL.CHEM., 278:42300-42306, 2003; PubMed: 12904298; DOI: 10.1074/jbc.M306147200

実験手法

X-RAY DIFFRACTION (2.1 Å)