1PME
STRUCTURE OF PENTA MUTANT HUMAN ERK2 MAP KINASE COMPLEXED WITH A SPECIFIC INHIBITOR OF HUMAN P38 MAP KINASE
Summary for 1PME
Entry DOI | 10.2210/pdb1pme/pdb |
Descriptor | ERK2, SULFATE ION, 4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE, ... (4 entities in total) |
Functional Keywords | map kinase, serine/threonine protein kinase, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P28482 |
Total number of polymer chains | 1 |
Total formula weight | 44089.60 |
Authors | |
Primary citation | Fox, T.,Coll, J.T.,Xie, X.,Ford, P.J.,Germann, U.A.,Porter, M.D.,Pazhanisamy, S.,Fleming, M.A.,Galullo, V.,Su, M.S.,Wilson, K.P. A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase. Protein Sci., 7:2249-2255, 1998 Cited by PubMed: 9827991PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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