Crystal structure of human mitochondrial NAD(P)+-dependent malic enzyme in a pentary complex with natural substrate malate, cofactor NADH, Mn++, and allosteric activator fumarate

Summary for 1PJ2

Related1PJ3 1PJ4
DescriptorNAD-dependent malic enzyme, mitochondrial, (2S)-2-hydroxybutanedioic acid, MANGANESE (II) ION, ... (6 entities in total)
Functional Keywordsoxidative decarboxylase, oxidoreductase
Biological sourceHomo sapiens (human)
Cellular locationMitochondrion matrix P23368
Total number of polymer chains4
Total molecular weight262116.59
Tao, X.,Yang, Z.,Tong, L. (deposition date: 2003-05-30, release date: 2003-11-11, Last modification date: 2018-03-21)
Primary citation
Tao, X.,Yang, Z.,Tong, L.
Crystal structures of substrate complexes of malic enzyme and insights into the catalytic mechanism.
Structure, 11:1141-1150, 2003
PubMed: 12962632 (PDB entries with the same primary citation)
DOI: 10.1016/S0969-2126(03)00168-0
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.257190.5%4.3%4.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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