Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

1PF8

Crystal Structure of Human Cyclin-Dependent Kinase 2 Complexed with a Nucleoside Inhibitor

Summary for 1PF8
Entry DOI10.2210/pdb1pf8/pdb
Related1HCK
DescriptorCell division protein kinase 2, (3Z)-3-(1H-IMIDAZOL-5-YLMETHYLENE)-5-METHOXY-1H-INDOL-2(3H)-ONE (2 entities in total)
Functional Keywordstransferase, serine/threonine protein kinase, atp-binding, cell cycle, cell division, mitosis, phosphorylation, su9516, inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941
Total number of polymer chains1
Total formula weight34217.73
Authors
Moshinsky, D.J.,Bellamacina, R.C.,Boisvert, D.C.,Huang, P.,Hui, T.,Jancarik, J.,Kim, S.H.,Rice, A.G. (deposition date: 2003-05-24, release date: 2003-12-23, Last modification date: 2023-08-16)
Primary citationMoshinsky, D.J.,Bellamacina, C.R.,Boisvert, D.C.,Huang, P.,Hui, T.,Jancarik, J.,Kim, S.H.,Rice, A.G.
SU9516: biochemical analysis of cdk inhibition and crystal structure in complex with cdk2.
Biochem.Biophys.Res.Commun., 310:1026-1031, 2003
Cited by
PubMed: 14550307
DOI: 10.1016/j.bbrc.2003.09.114
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.51 Å)
Structure validation

217705

數據於2024-03-27公開中

PDB statisticsPDBj update infoContact PDBjnumon