1PF8
Crystal Structure of Human Cyclin-Dependent Kinase 2 Complexed with a Nucleoside Inhibitor
Summary for 1PF8
Entry DOI | 10.2210/pdb1pf8/pdb |
Related | 1HCK |
Descriptor | Cell division protein kinase 2, (3Z)-3-(1H-IMIDAZOL-5-YLMETHYLENE)-5-METHOXY-1H-INDOL-2(3H)-ONE (2 entities in total) |
Functional Keywords | transferase, serine/threonine protein kinase, atp-binding, cell cycle, cell division, mitosis, phosphorylation, su9516, inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941 |
Total number of polymer chains | 1 |
Total formula weight | 34217.73 |
Authors | Moshinsky, D.J.,Bellamacina, R.C.,Boisvert, D.C.,Huang, P.,Hui, T.,Jancarik, J.,Kim, S.H.,Rice, A.G. (deposition date: 2003-05-24, release date: 2003-12-23, Last modification date: 2023-08-16) |
Primary citation | Moshinsky, D.J.,Bellamacina, C.R.,Boisvert, D.C.,Huang, P.,Hui, T.,Jancarik, J.,Kim, S.H.,Rice, A.G. SU9516: biochemical analysis of cdk inhibition and crystal structure in complex with cdk2. Biochem.Biophys.Res.Commun., 310:1026-1031, 2003 Cited by PubMed: 14550307DOI: 10.1016/j.bbrc.2003.09.114 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.51 Å) |
Structure validation
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