1PEN

ALPHA-CONOTOXIN PNI1

Summary for 1PEN

• Entry DOI: 10.2210/pdb1pen/pdb
• Descriptor: ALPHA-CONOTOXIN PNIA (2 entities in total)
• Functional Keywords: neurotoxin, acetylcholine receptor, postsynaptic, antagonist, acetylcholine receptor inhibitor
• Biological source: Conus pennaceus
• Cellular location: Secreted: P50984
• Total number of polymer chains: 1
• Total formula weight: 1625.85

Authors

Hu, S.-H.,Gehrmann, J.,Guddat, L.W.,Alewood, P.F.,Craik, D.J.,Martin, J.L. (deposition date: 1996-01-29, release date: 1997-04-21, Last modification date: 2024-10-16)

Primary citation

Hu, S.H.,Gehrmann, J.,Guddat, L.W.,Alewood, P.F.,Craik, D.J.,Martin, J.L.
The 1.1 A crystal structure of the neuronal acetylcholine receptor antagonist, alpha-conotoxin PnIA from Conus pennaceus.
Structure, 4:417-423, 1996

PubMed Abstract: alpha-Conotoxins are peptide toxins, isolated from Conus snails, that block the nicotinic acetylcholine receptor (nAChR). The 16-residue peptides PnIA and PnIB from Conus pennaceus incorporate the same disulfide framework as other alpha-conotoxins but differ in function from most alpha-conotoxins by blocking the neuronal nAChR, rather than the skeletal muscle subtype. The crystal structure determination of PnIA was undertaken to identify structural and surface features that might be important for biological activity.

PubMed: 8740364
DOI: 10.1016/S0969-2126(96)00047-0

Experimental method

X-RAY DIFFRACTION (1.1 Å)