1PEN

ALPHA-CONOTOXIN PNI1

1PEN の概要

• エントリーDOI: 10.2210/pdb1pen/pdb
• 分子名称: ALPHA-CONOTOXIN PNIA (2 entities in total)
• 機能のキーワード: neurotoxin, acetylcholine receptor, postsynaptic, antagonist, acetylcholine receptor inhibitor
• 由来する生物種: Conus pennaceus
• 細胞内の位置: Secreted: P50984
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 1625.85

構造登録者

Hu, S.-H.,Gehrmann, J.,Guddat, L.W.,Alewood, P.F.,Craik, D.J.,Martin, J.L. (登録日: 1996-01-29, 公開日: 1997-04-21, 最終更新日: 2024-10-16)

主引用文献

Hu, S.H.,Gehrmann, J.,Guddat, L.W.,Alewood, P.F.,Craik, D.J.,Martin, J.L.
The 1.1 A crystal structure of the neuronal acetylcholine receptor antagonist, alpha-conotoxin PnIA from Conus pennaceus.
Structure, 4:417-423, 1996

PubMed Abstract: alpha-Conotoxins are peptide toxins, isolated from Conus snails, that block the nicotinic acetylcholine receptor (nAChR). The 16-residue peptides PnIA and PnIB from Conus pennaceus incorporate the same disulfide framework as other alpha-conotoxins but differ in function from most alpha-conotoxins by blocking the neuronal nAChR, rather than the skeletal muscle subtype. The crystal structure determination of PnIA was undertaken to identify structural and surface features that might be important for biological activity.

PubMed: 8740364
DOI: 10.1016/S0969-2126(96)00047-0

実験手法

X-RAY DIFFRACTION (1.1 Å)