1PDG

CRYSTAL STRUCTURE OF HUMAN PLATELET-DERIVED GROWTH FACTOR BB

1PDG の概要

• エントリーDOI: 10.2210/pdb1pdg/pdb
• 分子名称: PLATELET-DERIVED GROWTH FACTOR BB (1 entity in total)
• 機能のキーワード: growth factor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P01127
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 36940.50

構造登録者

Oefner, C.,Darcy, A.D.,Winkler, F.K.,Eggimann, B.,Hosnag, M. (登録日: 1992-07-14, 公開日: 1994-01-31, 最終更新日: 2024-11-13)

主引用文献

Oefner, C.,D'Arcy, A.,Winkler, F.K.,Eggimann, B.,Hosang, M.
Crystal structure of human platelet-derived growth factor BB.
EMBO J., 11:3921-3926, 1992

PubMed Abstract: The crystal structure of the homodimeric BB isoform of human recombinant platelet-derived growth factor (PDGF-BB) has been determined by X-ray analysis to 3.0 A resolution. The polypeptide chain is folded into two highly twisted antiparallel pairs of beta-strands and contains an unusual knotted arrangement of three intramolecular disulfide bonds. Dimerization leads to the clustering of three surface loops at each end of the elongated dimer, which most probably form the receptor recognition sites.

PubMed: 1396586

実験手法

X-RAY DIFFRACTION (3 Å)