1PD9

Analysis of Three Crystal Structure Determinations of a 5-Methyl-6-N-Methylanilino Pyridopyrimidine antifolate Complex with Human Dihydrofolate Reductase

Summary for 1PD9

Entry DOI	10.2210/pdb1pd9/pdb
Related	1PD8 1PDB
Descriptor	Dihydrofolate reductase, SULFATE ION, 2,4-DIAMINO-5-METHYL-6-[(3,4,5-TRIMETHOXY-N-METHYLANILINO)METHYL]PYRIDO[2,3-D]PYRIMIDINE, ... (4 entities in total)
Functional Keywords	human dihydrofolate reductase inhibitor complexes, oxidoreductase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	21926.08
Authors	Cody, V.,Luft, J.R.,Pangborn, W.,Gangjee, A. (deposition date: 2003-05-19, release date: 2003-12-09, Last modification date: 2023-08-16)
Primary citation	Cody, V.,Luft, J.R.,Pangborn, W.,Gangjee, A. Analysis of three crystal structure determinations of a 5-methyl-6-N-methylanilino pyridopyrimidine antifolate complex with human dihydrofolate reductase. Acta Crystallogr.,Sect.D, 59:1603-1609, 2003 Cited by PubMed: 12925791 DOI: 10.1107/S0907444903014963 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation