1PD8

Analysis of Three Crystal Structure Determinations of a 5-Methyl-6-N-Methylanilino Pyridopyrimidine Antifolate Complex with Human Dihydrofolate Reductase

1PD8 の概要

• エントリーDOI: 10.2210/pdb1pd8/pdb
• 関連するPDBエントリー: 1PD9 1PDB
• 分子名称: Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2,4-DIAMINO-5-METHYL-6-[(3,4,5-TRIMETHOXY-N-METHYLANILINO)METHYL]PYRIDO[2,3-D]PYRIMIDINE, ... (4 entities in total)
• 機能のキーワード: human dihydrofolate reductase inhibitor complex, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22479.38

構造登録者

Cody, V.,Luft, J.R.,Pangborn, W.,Gangjee, A. (登録日: 2003-05-19, 公開日: 2003-12-09, 最終更新日: 2023-08-16)

• 主引用文献: Cody, V.,Luft, J.R.,Pangborn, W.,Gangjee, A.; Analysis of three crystal structure determinations of a 5-methyl-6-N-methylanilino pyridopyrimidine antifolate complex with human dihydrofolate reductase.; Acta Crystallogr.,Sect.D, 59:1603-1609, 2003; PubMed: 12925791; DOI: 10.1107/S0907444903014963

実験手法

X-RAY DIFFRACTION (2.1 Å)