1PCW

Aquifex aeolicus KDO8PS in complex with cadmium and APP, a bisubstrate inhibitor

Summary for 1PCW

• Entry DOI: 10.2210/pdb1pcw/pdb
• Related: 1JCX
• Descriptor: 2-dehydro-3-deoxyphosphooctonate aldolase, CADMIUM ION, 1-DEOXY-6-O-PHOSPHONO-1-[(PHOSPHONOMETHYL)AMINO]-L-THREO-HEXITOL, ... (4 entities in total)
• Functional Keywords: beta(8)/alpha(8) barrel, lyase
• Biological source: Aquifex aeolicus
• Cellular location: Cytoplasm (By similarity): O66496
• Total number of polymer chains: 2
• Total formula weight: 60483.98

Authors

Xu, X.,Wang, J.,Grison, C.,Petek, S.,Coutrot, P.,Birck, M.,Woodard, R.W.,Gatti, D.L. (deposition date: 2003-05-17, release date: 2004-02-17, Last modification date: 2023-08-16)

• Primary citation: Xu, X.,Wang, J.,Grison, C.,Petek, S.,Coutrot, P.,Birck, M.R.,Woodard, R.W.,Gatti, D.L.; Structure-Based Design of Novel Inhibitors of 3-Deoxy-D-manno-octulosonate 8-Phosphate Synthase.; Drug DES.DISCOVERY, 18:91-99, 2003; PubMed: 14675946

Experimental method

X-RAY DIFFRACTION (1.85 Å)