1PCG

Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor-coactivator interactions

1PCG の概要

• エントリーDOI: 10.2210/pdb1pcg/pdb
• 分子名称: estrogen receptor, peptide inhibitor, ESTRADIOL, ... (4 entities in total)
• 機能のキーワード: co-activator binding site, transcription-inhibitor complex, transcription/inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform 1: Nucleus. Isoform 3: Nucleus: P03372
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 58362.82

構造登録者

Leduc, A.M.,Trent, J.O.,Wittliff, J.L.,Bramlett, K.S.,Briggs, S.L.,Chirgadze, N.Y.,Wang, Y.,Burris, T.P.,Spatola, A.F. (登録日: 2003-05-16, 公開日: 2003-10-28, 最終更新日: 2021-10-27)

• 主引用文献: Leduc, A.M.,Trent, J.O.,Wittliff, J.L.,Bramlett, K.S.,Briggs, S.L.,Chirgadze, N.Y.,Wang, Y.,Burris, T.P.,Spatola, A.F.; Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor-coactivator interactions; Proc.Natl.Acad.Sci.USA, 100:11273-11278, 2003; PubMed: 13679575; DOI: 10.1073/pnas.1934759100

実験手法

X-RAY DIFFRACTION (2.7 Å)