1PCF

HUMAN TRANSCRIPTIONAL COACTIVATOR PC4 C-TERMINAL DOMAIN

1PCF の概要

• エントリーDOI: 10.2210/pdb1pcf/pdb
• 分子名称: TRANSCRIPTIONAL COACTIVATOR PC4 (2 entities in total)
• 機能のキーワード: transcription, transcriptional cofactor, transcriptional co-activator, ssdna binding, nuclear protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: P53999
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 62272.19

構造登録者

Brandsen, J.,Gros, P. (登録日: 1997-09-09, 公開日: 1998-03-18, 最終更新日: 2024-02-14)

主引用文献

Brandsen, J.,Werten, S.,van der Vliet, P.C.,Meisterernst, M.,Kroon, J.,Gros, P.
C-terminal domain of transcription cofactor PC4 reveals dimeric ssDNA binding site.
Nat.Struct.Biol., 4:900-903, 1997

PubMed Abstract: The crystal structure of human replication and transcription cofactor PC4CTD reveals a dimer with two single-stranded (ss)DNA binding channels running in opposite directions to each other. This arrangement suggests a role in establishment or maintenance of melted DNA at promoters or origins of replication.

PubMed: 9360603
DOI: 10.1038/nsb1197-900

実験手法

X-RAY DIFFRACTION (1.74 Å)