1PBO

COMPLEX OF BOVINE ODORANT BINDING PROTEIN (OBP) WITH A SELENIUM CONTAINING ODORANT

1PBO の概要

• エントリーDOI: 10.2210/pdb1pbo/pdb
• 分子名称: ODORANT BINDING PROTEIN, 4-butyl-5-propyl-1,3-selenazol-2-amine (3 entities in total)
• 機能のキーワード: odorant-binding, transport, lipocalin
• 由来する生物種: Bos taurus (cattle)
• 細胞内の位置: Secreted: P07435
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 37461.21

構造登録者

Amzel, L.M.,Bianchet, M.A.,Monaco, H.,Bains, G. (登録日: 1996-07-15, 公開日: 1997-07-23, 最終更新日: 2024-02-14)

主引用文献

Bianchet, M.A.,Bains, G.,Pelosi, P.,Pevsner, J.,Snyder, S.H.,Monaco, H.L.,Amzel, L.M.
The three-dimensional structure of bovine odorant binding protein and its mechanism of odor recognition.
Nat.Struct.Biol., 3:934-939, 1996

PubMed Abstract: Odorant binding protein (OBP) is the major odorant binding component of mammalian nasal mucosa. The two structures of bovine OBP reported in this paper (one crystallized as purified and one soaked in the presence of a selenium-containing odorant) show that: (i) the OBP dimer is composed of two compact domains related by an approximate two-fold axis of symmetry; (ii) between residues 122 and 123 the polypeptide chains cross from one domain to the other such that each domain is formed by residues from both monomers; (iii) purified OBP already contains two bound odorant molecules (one per monomer)-odorant binding occurs by replacement of these molecules with the added odorant; and (iv) the structure of the odorant binding site can explain OBP's extraordinarily broad odorant specificity.

PubMed: 8901871
DOI: 10.1038/nsb1196-934

実験手法

X-RAY DIFFRACTION (2.2 Å)