1P8V

CRYSTAL STRUCTURE OF THE COMPLEX OF PLATELET RECEPTOR GPIB-ALPHA AND ALPHA-THROMBIN AT 2.6A

1P8V の概要

• エントリーDOI: 10.2210/pdb1p8v/pdb
• 分子名称: Platelet glycoprotein Ib alpha chain, Prothrombin, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (7 entities in total)
• 機能のキーワード: platelet glycoprotein receptor, leucine rich repeat domain, membrane protein-hydrolase complex, membrane protein/hydrolase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 65037.33

構造登録者

Dumas, J.J.,Kumar, R.,Seehra, J.,Somers, W.S.,Mosyak, L. (登録日: 2003-05-07, 公開日: 2003-07-22, 最終更新日: 2024-12-25)

主引用文献

Dumas, J.J.,Kumar, R.,Seehra, J.,Somers, W.S.,Mosyak, L.
Crystal Structure of the GpIbalpha-Thrombin Complex Essential for Platelet Aggregation
Science, 301:222-226, 2003

PubMed Abstract: Direct interaction between platelet receptor glycoprotein Ibalpha (GpIbalpha) and thrombin is required for platelet aggregation and activation at sites of vascular injury. Abnormal GpIbalpha-thrombin binding is associated with many pathological conditions,including occlusive arterial thrombosis and bleeding disorders. The crystal structure of the GpIbalpha-thrombin complex at 2.6 angstrom resolution reveals simultaneous interactions of GpIbalpha with exosite I of one thrombin molecule,and with exosite II of a second thrombin molecule. In the crystal lattice,the periodic arrangement of GpIbalpha-thrombin complexes mirrors a scaffold that could serve as a driving force for tight platelet adhesion. The details of these interactions reconcile GpIbalpha-thrombin binding modes that are presently controversial,highlighting two distinct interfaces that are potential targets for development of novel antithrombotic drugs.

PubMed: 12855811
DOI: 10.1126/science.1083917

実験手法

X-RAY DIFFRACTION (2.6 Å)