1P6B

X-ray structure of phosphotriesterase, triple mutant H254G/H257W/L303T

1P6B の概要

• エントリーDOI: 10.2210/pdb1p6b/pdb
• 分子名称: Parathion hydrolase, ZINC ION, DIETHYL 4-METHYLBENZYLPHOSPHONATE, ... (5 entities in total)
• 機能のキーワード: metalloenzyme, tim barrel, nerve agents, hydrolase
• 由来する生物種: Flavobacterium sp.
• 細胞内の位置: Cell membrane ; Peripheral membrane protein : P0A433
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 73663.63

構造登録者

Hill, C.M.,Li, W.,Thoden, J.B.,Holden, H.M.,Raushel, F.M. (登録日: 2003-04-29, 公開日: 2003-09-16, 最終更新日: 2023-11-15)

• 主引用文献: Hill, C.M.,Li, W.S.,Thoden, J.B.,Holden, H.M.,Raushel, F.M.; Enhanced degradation of chemical warfare agents through molecular engineering of the phosphotriesterase active site.; J.Am.Chem.Soc., 125:8990-8991, 2003; PubMed: 15369336; DOI: 10.1021/ja0358798

実験手法

X-RAY DIFFRACTION (1.9 Å)