The structure of phospho-CDK2/cyclin A in complex with the inhibitor 4,5,6,7-tetrabromobenzotriazole (TBS)

Summary for 1P5E

DescriptorCell division protein kinase 2, Cyclin A2, 4,5,6,7-TETRABROMOBENZOTRIAZOLE, ... (4 entities in total)
Functional Keywordskinase inhibitor, cdk2, tbs, cell cycle
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm, cytoskeleton, microtubule organizing center, centrosome P24941
Nucleus  P20248
Total number of polymer chains4
Total molecular weight128405.1
De Moliner, E.,Brown, N.R.,Johnson, L.N. (deposition date: 2003-04-26, release date: 2003-07-01, Last modification date: 2016-12-21)
Primary citation
De Moliner, E.,Brown, N.R.,Johnson, L.N.
Alternative binding modes of an inhibitor to two different kinases
Eur.J.Biochem., 270:1-8, 2003
PubMed: 12869192 (PDB entries with the same primary citation)
DOI: 10.1046/j.1432-1033.2003.03697.x
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.24771.3%6.1%7.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report