1P5E

The structure of phospho-CDK2/cyclin A in complex with the inhibitor 4,5,6,7-tetrabromobenzotriazole (TBS)

1P5E の概要

• エントリーDOI: 10.2210/pdb1p5e/pdb
• 分子名称: Cell division protein kinase 2, Cyclin A2, 4,5,6,7-TETRABROMOBENZOTRIAZOLE, ... (4 entities in total)
• 機能のキーワード: kinase inhibitor, cdk2, tbs, cell cycle
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941; Nucleus : P20248
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 128405.10

構造登録者

De Moliner, E.,Brown, N.R.,Johnson, L.N. (登録日: 2003-04-26, 公開日: 2003-07-01, 最終更新日: 2016-12-21)

• 主引用文献: De Moliner, E.,Brown, N.R.,Johnson, L.N.; Alternative binding modes of an inhibitor to two different kinases; Eur.J.Biochem., 270:1-8, 2003; PubMed: 12869192; DOI: 10.1046/j.1432-1033.2003.03697.x

実験手法

X-RAY DIFFRACTION (2.22 Å)