1P57

Extracellular domain of human hepsin

1P57 の概要

• エントリーDOI: 10.2210/pdb1p57/pdb
• 分子名称: Serine protease hepsin, 2-{5-[AMINO(IMINIO)METHYL]-1H-BENZIMIDAZOL-2-YL}BENZENOLATE, ... (4 entities in total)
• 機能のキーワード: srcr, scavenger receptor cysteine-rich domain, serine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cell membrane ; Single-pass type II membrane protein : P05981 P05981
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 40347.68

構造登録者

Somoza, J.R.,Ho, J.D.,Luong, C.,Sprengeler, P.A.,Mortara, K.,Shrader, W.D.,Sperandio, D.,Chan, H.,McGrath, M.E.,Katz, B.A. (登録日: 2003-04-25, 公開日: 2004-01-20, 最終更新日: 2024-10-30)

主引用文献

Somoza, J.R.,Ho, J.D.,Luong, C.,Ghate, M.,Sprengeler, P.A.,Mortara, K.,Shrader, W.D.,Sperandio, D.,Chan, H.,McGrath, M.E.,Katz, B.A.
The Structure of the Extracellular Region of Human Hepsin Reveals a Serine Protease Domain and a Novel Scavenger Receptor Cysteine-Rich (SRCR) Domain
Structure, 11:1123-1131, 2003

PubMed Abstract: Hepsin is an integral membrane protein that may participate in cell growth and in maintaining proper cell morphology and is overexpressed in a number of primary tumors. We have determined the 1.75 A resolution structure of the extracellular component of human hepsin. This structure includes a 255-residue trypsin-like serine protease domain and a 109-residue region that forms a novel, poorly conserved, scavenger receptor cysteine-rich (SRCR) domain. The two domains are associated with each other through a single disulfide bond and an extensive network of noncovalent interactions. The structure suggests how the extracellular region of hepsin may be positioned with respect to the plasma membrane.

PubMed: 12962630
DOI: 10.1016/S0969-2126(03)00148-5

実験手法

X-RAY DIFFRACTION (1.75 Å)