1P4R
Crystal Structure of Human ATIC in complex with folate-based inhibitor BW1540U88UD
Summary for 1P4R
Entry DOI | 10.2210/pdb1p4r/pdb |
Descriptor | Bifunctional purine biosynthesis protein PURH, POTASSIUM ION, AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, ... (6 entities in total) |
Functional Keywords | antifolate, atic, purine biosynthesis, bw1540u88ud, transferase, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 131494.25 |
Authors | Cheong, C.-G.,Greasley, S.E.,Horton, P.A.,Beardsley, G.P.,Wilson, I.A. (deposition date: 2003-04-23, release date: 2004-03-30, Last modification date: 2023-08-16) |
Primary citation | Cheong, C.-G.,Wolan, D.W.,Greasley, S.E.,Horton, P.A.,Beardsley, G.P.,Wilson, I.A. Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates J.Biol.Chem., 279:18034-18045, 2004 Cited by PubMed: 14966129DOI: 10.1074/jbc.M313691200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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