1P4R

Crystal Structure of Human ATIC in complex with folate-based inhibitor BW1540U88UD

Summary for 1P4R

Entry DOI	10.2210/pdb1p4r/pdb
Descriptor	Bifunctional purine biosynthesis protein PURH, POTASSIUM ION, AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, ... (6 entities in total)
Functional Keywords	antifolate, atic, purine biosynthesis, bw1540u88ud, transferase, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	131494.25
Authors	Cheong, C.-G.,Greasley, S.E.,Horton, P.A.,Beardsley, G.P.,Wilson, I.A. (deposition date: 2003-04-23, release date: 2004-03-30, Last modification date: 2023-08-16)
Primary citation	Cheong, C.-G.,Wolan, D.W.,Greasley, S.E.,Horton, P.A.,Beardsley, G.P.,Wilson, I.A. Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates J.Biol.Chem., 279:18034-18045, 2004 Cited by PubMed: 14966129 DOI: 10.1074/jbc.M313691200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.55 Å)

Structure validation