1P4R

Crystal Structure of Human ATIC in complex with folate-based inhibitor BW1540U88UD

1P4R の概要

• エントリーDOI: 10.2210/pdb1p4r/pdb
• 分子名称: Bifunctional purine biosynthesis protein PURH, POTASSIUM ION, AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, ... (6 entities in total)
• 機能のキーワード: antifolate, atic, purine biosynthesis, bw1540u88ud, transferase, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 131494.25

構造登録者

Cheong, C.-G.,Greasley, S.E.,Horton, P.A.,Beardsley, G.P.,Wilson, I.A. (登録日: 2003-04-23, 公開日: 2004-03-30, 最終更新日: 2023-08-16)

• 主引用文献: Cheong, C.-G.,Wolan, D.W.,Greasley, S.E.,Horton, P.A.,Beardsley, G.P.,Wilson, I.A.; Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates; J.Biol.Chem., 279:18034-18045, 2004; PubMed: 14966129; DOI: 10.1074/jbc.M313691200

実験手法

X-RAY DIFFRACTION (2.55 Å)