1OYT

COMPLEX OF RECOMBINANT HUMAN THROMBIN WITH A DESIGNED FLUORINATED INHIBITOR

1OYT の概要

• エントリーDOI: 10.2210/pdb1oyt/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000481
• 分子名称: thrombin light chain, thrombin heavy chain, Hirudin IIB, ... (7 entities in total)
• 機能のキーワード: serine proteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted, extracellular space: P00734 P00734; Secreted: P28506
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 35743.73

構造登録者

Banner, D.W.,Olsen, J.A. (登録日: 2003-04-07, 公開日: 2003-06-24, 最終更新日: 2024-04-03)

• 主引用文献: Olsen, J.A.,Banner, D.W.,Seiler, P.,Obst-Sander, U.,D'Arcy, A.,Stihle, M.,Mueller, K.,Diederich, F.; A Fluorine Scan of Thrombin Inhibitors to Map the Fluorophilicity/Fluorophobicity of an Enzyme Active Site: Evidence for CF...C=O Interactions.; Angew.Chem.Int.Ed.Engl., 42:2507-2511, 2003; PubMed: 12800172; DOI: 10.1002/anie.200351268

実験手法

X-RAY DIFFRACTION (1.67 Å)