1OYH

Crystal Structure of P13 Alanine Variant of Antithrombin

1OYH の概要

• エントリーDOI: 10.2210/pdb1oyh/pdb
• 関連するPDBエントリー: 1E04 1NQ9
• 分子名称: Antithrombin-III, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: thrombin; inhibition; heparin analogue; serine protease inhibitor, blood clotting
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted, extracellular space: P01008 P01008
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 100772.45

構造登録者

Johnson, D.J.D.,Huntington, J.A. (登録日: 2003-04-04, 公開日: 2004-04-13, 最終更新日: 2023-08-16)

• 主引用文献: Johnson, D.J.D.,Huntington, J.A.; The influence of hinge region residue Glu-381 on antithrombin allostery and metastability; J.Biol.Chem., 279:4913-4921, 2004; PubMed: 14623882; DOI: 10.1074/jbc.M311644200

実験手法

X-RAY DIFFRACTION (2.62 Å)