1OT5

The 2.4 Angstrom Crystal Structure of Kex2 in complex with a peptidyl-boronic acid inhibitor

1OT5 の概要

• エントリーDOI: 10.2210/pdb1ot5/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000411
• 分子名称: Kexin, Ac-Ala-Lys-boroArg N-acetylated boronic acid peptide inhibitor, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: subtilisin fold, peptidyl-boronic acid, serine protease, p-domain, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Saccharomyces cerevisiae (baker's yeast); 詳細
• 細胞内の位置: Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein: P13134
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 106699.26

構造登録者

Holyoak, T.,Wilson, M.A.,Fenn, T.D.,Kettner, C.A.,Petsko, G.A.,Fuller, R.S.,Ringe, D. (登録日: 2003-03-21, 公開日: 2003-06-17, 最終更新日: 2020-07-29)

• 主引用文献: Holyoak, T.,Wilson, M.A.,Fenn, T.D.,Kettner, C.A.,Petsko, G.A.,Fuller, R.S.,Ringe, D.; 2.4 A Resolution Crystal Structure of the Prototypical Hormone-Processing Protease Kex2 in Complex with an Ala-Lys-Arg Boronic Acid Inhibitor; Biochemistry, 42:6709-6718, 2003; PubMed: 12779325; DOI: 10.1021/bi034434t

実験手法

X-RAY DIFFRACTION (2.4 Å)