1OON

Nitroreductase from e-coli in complex with the dinitrobenzamide prodrug SN27217

1OON の概要

• エントリーDOI: 10.2210/pdb1oon/pdb
• 関連するPDBエントリー: 1DS7 1IDT 1OO5 1OO6 1OOQ
• 分子名称: Oxygen-insensitive NAD(P)H nitroreductase, FLAVIN MONONUCLEOTIDE, 2,4-DINITRO,5-[BIS(2-BROMOETHYL)AMINO]-N-(2',3'-DIOXOPROPYL)BENZAMIDE, ... (4 entities in total)
• 機能のキーワード: nad(p)h-quinone reductase, fmn, nitroreductase, flavoprotein, sn27217, oxidoreductase
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 49297.14

構造登録者

Johansson, E.,Parkinson, G.N.,Denny, W.A.,Neidle, S. (登録日: 2003-03-04, 公開日: 2003-04-08, 最終更新日: 2023-08-16)

• 主引用文献: Johansson, E.,Parkinson, G.N.,Denny, W.A.,Neidle, S.; Studies on the Nitroreductase Prodrug-Activating System. Crystal Structures of Complexes with the Inhibitor Dicoumarol and Dinitrobenzamide Prodrugs and of the Enzyme Active Form; J.Med.Chem., 46:4009-4020, 2003; PubMed: 12954054; DOI: 10.1021/jm030843b

実験手法

X-RAY DIFFRACTION (2.49 Å)