1OO8

CRYSTAL STRUCTURE OF A1PI-PITTSBURGH IN THE NATIVE CONFORMATION

Summary for 1OO8

Entry DOI	10.2210/pdb1oo8/pdb
Descriptor	Alpha-1-antitrypsin precursor (2 entities in total)
Functional Keywords	serpin, pittsburgh variant, hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Secreted. Short peptide from AAT: Secreted, extracellular space, extracellular matrix: P01009
Total number of polymer chains	1
Total formula weight	44276.26
Authors	Dementiev, A.,Simonovic, M.,Volz, K.,Gettins, P.G. (deposition date: 2003-03-03, release date: 2003-08-05, Last modification date: 2023-08-16)
Primary citation	Dementiev, A.,Simonovic, M.,Volz, K.,Gettins, P.G. Canonical inhibitor-like interactions explain reactivity of alpha1-proteinase inhibitor Pittsburgh and antithrombin with proteinases J.Biol.Chem., 278:37881-37887, 2003 Cited by PubMed: 12860985 DOI: 10.1074/jbc.M305195200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.65 Å)

Structure validation