1OO5
Studies on the Nitroreductase Prodrug-Activating System. Crystal Structures of the Enzyme Active Form and Complexes with the Inhibitor Dicoumarol and Dinitrobenzamide Prodrugs
Summary for 1OO5
Entry DOI | 10.2210/pdb1oo5/pdb |
Related | 1IDT |
Descriptor | Oxygen-insensitive NAD(P)H nitroreductase, FLAVIN MONONUCLEOTIDE (3 entities in total) |
Functional Keywords | nad(p)h-quinone reductase, fmn, nitroreductase, flavoprotein, oxidoreductase |
Biological source | Escherichia coli |
Total number of polymer chains | 2 |
Total formula weight | 48787.05 |
Authors | Johansson, E.,Parkinson, G.N.,Denny, W.A.,Neidle, S. (deposition date: 2003-03-03, release date: 2003-04-08, Last modification date: 2023-08-16) |
Primary citation | Johansson, E.,Parkinson, G.N.,Denny, W.A.,Neidle, S. Studies on the Nitroreductase Prodrug-Activating System. Crystal Structures of Complexes with the Inhibitor Dicoumarol and Dinitrobenzamide Prodrugs and of the Enzyme Active Form J.Med.Chem., 46:4009-4020, 2003 Cited by PubMed: 12954054DOI: 10.1021/jm030843b PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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