1OO5

Studies on the Nitroreductase Prodrug-Activating System. Crystal Structures of the Enzyme Active Form and Complexes with the Inhibitor Dicoumarol and Dinitrobenzamide Prodrugs

1OO5 の概要

関連するPDBエントリー1IDT
分子名称Oxygen-insensitive NAD(P)H nitroreductase, FLAVIN MONONUCLEOTIDE (3 entities in total)
機能のキーワードnad(p)h-quinone reductase, fmn, nitroreductase, flavoprotein, oxidoreductase
由来する生物種Escherichia coli
ポリマー鎖数2
分子量合計48787.05
構造登録者
Johansson, E.,Parkinson, G.N.,Denny, W.A.,Neidle, S. (登録日: 2003-03-03, 公開日: 2003-04-08, 最終更新日: 2011-07-13)
主引用文献
Johansson, E.,Parkinson, G.N.,Denny, W.A.,Neidle, S.
Studies on the Nitroreductase Prodrug-Activating System. Crystal Structures of Complexes with the Inhibitor Dicoumarol and Dinitrobenzamide Prodrugs and of the Enzyme Active Form
J.Med.Chem., 46:4009-4020, 2003
PubMed: 12954054 (主引用文献が同じPDBエントリー)
DOI: 10.1021/jm030843b
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.5 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.299100.2%14.5%3.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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