1ONB

Solution structure of an engineered arginine-rich subdomain 2 of the hepatitis C virus NS3 RNA helicase

1ONB の概要

• エントリーDOI: 10.2210/pdb1onb/pdb
• 関連するPDBエントリー: 1JR6
• 分子名称: helicase NS3 (1 entity in total)
• 機能のキーワード: alpha-beta-alpha, hydrolase
• 由来する生物種: Hepatitis C virus
• 細胞内の位置: Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein. Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein. Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein. RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P27958
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15149.27

構造登録者

Liu, D.,Wang, Y.S.,Gesell, J.J.,Wyss, D.F. (登録日: 2003-02-27, 公開日: 2003-03-11, 最終更新日: 2022-02-23)

• 主引用文献: Liu, D.,Wang, Y.S.,Gesell, J.J.,Wyss, D.F.; Solution structure and backbone dynamics of an engineered arginine-rich subdomain 2 of the hepatitis C virus NS3 RNA helicase; J.Mol.Biol., 314:543-561, 2001; PubMed: 11846566; DOI: 10.1006/jmbi.2001.5146

実験手法

SOLUTION NMR