1ON8

Crystal structure of mouse alpha-1,4-N-acetylhexosaminyltransferase (EXTL2) with UDP and GlcUAb(1-3)Galb(1-O)-naphthalenelmethanol an acceptor substrate analog

Summary for 1ON8

Entry DOI	10.2210/pdb1on8/pdb
Related	1OMX 1OMZ 1ON6
Descriptor	Alpha-1,4-N-acetylhexosaminyltransferase EXTL2, beta-D-glucopyranuronic acid-(1-3)-beta-D-galactopyranose, MANGANESE (II) ION, ... (6 entities in total)
Functional Keywords	rossmann fold, dxd motif, transferase
Biological source	Mus musculus (house mouse)
Cellular location	Endoplasmic reticulum membrane ; Single-pass type II membrane protein : Q9ES89
Total number of polymer chains	2
Total formula weight	68547.52
Authors	Pedersen, L.C.,Dong, J.,Taniguchi, F.,Kitagawa, H.,Krahn, J.M.,Pedersen, L.G.,Sugahara, K.,Negishi, M. (deposition date: 2003-02-27, release date: 2003-04-22, Last modification date: 2023-08-16)
Primary citation	Pedersen, L.C.,Dong, J.,Taniguchi, F.,Kitagawa, H.,Krahn, J.M.,Pedersen, L.G.,Sugahara, K.,Negishi, M. Crystal structure of an alpha-1,4-N-acetylhexosaminyltransferase (EXTL2), a member of the exostosin gene family involved in heparan sulfate biosynthesis J.Biol.Chem., 278:14420-14428, 2003 Cited by PubMed: 12562774 DOI: 10.1074/jbc.M210532200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation