1OKO
Crystal structure of Pseudomonas Aeruginosa Lectin 1 complexed with galactose at 1.6 A resolution
Summary for 1OKO
| Entry DOI | 10.2210/pdb1oko/pdb |
| Related | 1L7L 1UOJ |
| Descriptor | PA-I GALACTOPHILIC LECTIN, CALCIUM ION, beta-D-galactopyranose, ... (7 entities in total) |
| Functional Keywords | sugar binding protein, galactose binding |
| Biological source | PSEUDOMONAS AERUGINOSA |
| Total number of polymer chains | 4 |
| Total formula weight | 52908.32 |
| Authors | Cioci, G.,Mitchell, E.,Gautier, C.,Wimmerova, M.,Perez, S.,Gilboa-Garber, N.,Imberty, A. (deposition date: 2003-07-28, release date: 2003-12-04, Last modification date: 2024-05-01) |
| Primary citation | Cioci, G.,Mitchell, E.,Gautier, C.,Wimmerova, M.,Sudakevitz, D.,Perez, S.,Gilboa-Garber, N.,Imberty, A. Structural Basis of Calcium and Galactose Recognition by the Lectin Pa-Il of Pseudomonas Aeruginosa FEBS Lett., 555:297-, 2003 Cited by PubMed Abstract: The structure of the tetrameric Pseudomonas aeruginosa lectin I (PA-IL) in complex with galactose and calcium was determined at 1.6 A resolution, and the native protein was solved at 2.4 A resolution. Each monomer adopts a beta-sandwich fold with ligand binding site at the apex. All galactose hydroxyl groups, except O1, are involved in a hydrogen bond network with the protein and O3 and O4 also participate in the co-ordination of the calcium ion. The stereochemistry of calcium galactose binding is reminiscent of that observed in some animal C-type lectins. The structure of the complex provides a framework for future design of anti-bacterial compounds. PubMed: 14644431DOI: 10.1016/S0014-5793(03)01249-3 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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