1OKO

Crystal structure of Pseudomonas Aeruginosa Lectin 1 complexed with galactose at 1.6 A resolution

1OKO の概要

• エントリーDOI: 10.2210/pdb1oko/pdb
• 関連するPDBエントリー: 1L7L 1UOJ
• 分子名称: PA-I GALACTOPHILIC LECTIN, CALCIUM ION, beta-D-galactopyranose, ... (7 entities in total)
• 機能のキーワード: sugar binding protein, galactose binding
• 由来する生物種: PSEUDOMONAS AERUGINOSA
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 52908.32

構造登録者

Cioci, G.,Mitchell, E.,Gautier, C.,Wimmerova, M.,Perez, S.,Gilboa-Garber, N.,Imberty, A. (登録日: 2003-07-28, 公開日: 2003-12-04, 最終更新日: 2024-05-01)

主引用文献

Cioci, G.,Mitchell, E.,Gautier, C.,Wimmerova, M.,Sudakevitz, D.,Perez, S.,Gilboa-Garber, N.,Imberty, A.
Structural Basis of Calcium and Galactose Recognition by the Lectin Pa-Il of Pseudomonas Aeruginosa
FEBS Lett., 555:297-, 2003

PubMed Abstract: The structure of the tetrameric Pseudomonas aeruginosa lectin I (PA-IL) in complex with galactose and calcium was determined at 1.6 A resolution, and the native protein was solved at 2.4 A resolution. Each monomer adopts a beta-sandwich fold with ligand binding site at the apex. All galactose hydroxyl groups, except O1, are involved in a hydrogen bond network with the protein and O3 and O4 also participate in the co-ordination of the calcium ion. The stereochemistry of calcium galactose binding is reminiscent of that observed in some animal C-type lectins. The structure of the complex provides a framework for future design of anti-bacterial compounds.

PubMed: 14644431
DOI: 10.1016/S0014-5793(03)01249-3

実験手法

X-RAY DIFFRACTION (1.6 Å)