1OI1

Crystal Structure of the MBT domains of Human SCML2

1OI1 の概要

• エントリーDOI: 10.2210/pdb1oi1/pdb
• 分子名称: SCML2 PROTEIN, DI(HYDROXYETHYL)ETHER (3 entities in total)
• 機能のキーワード: mbt, scml2
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Nucleus : Q9UQR0
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24756.94

構造登録者

Sathyamurthy, A.,Allen, M.D.,Murzin, A.G.,Bycroft, M. (登録日: 2003-06-04, 公開日: 2003-06-15, 最終更新日: 2024-05-08)

主引用文献

Sathyamurthy, A.,Allen, M.D.,Murzin, A.G.,Bycroft, M.
Crystal Structure of the Malignant Brain Tumor (Mbt) Repeats in Sex Comb on Midleg-Like 2 (Scml2).
J.Biol.Chem., 278:46968-, 2003

PubMed Abstract: Sex Comb on Midleg (SCM) belongs to the Polycomb group of proteins, which are involved in transcriptional regulation in Drosophila. It is one of the components of Polycomb repressive complex 1, a multiprotein complex of Polycomb group proteins involved in the maintenance of repression and the blocking of chromatin remodeling. SCM contains two approximately 100-residue malignant brain tumor (MBT) repeats at the N terminus. These repeats are also found in other proteins involved in transcriptional repression. Here, we report the 1.78-A crystal structure of the two MBT repeats of SCM-like 2 (SCML2), a human homologue of SCM. Each repeat consists of an extended arm and a beta-barrel core. There are significant structural similarities to the Tudor, PWWP, and chromo domains, suggesting probable evolutionary relationships and functional similarities between the MBT repeats and these domains.

PubMed: 12952983
DOI: 10.1074/JBC.M306469200

実験手法

X-RAY DIFFRACTION (1.78 Å)