1OHJ
HUMAN DIHYDROFOLATE REDUCTASE, MONOCLINIC (P21) CRYSTAL FORM
Summary for 1OHJ
Entry DOI | 10.2210/pdb1ohj/pdb |
Descriptor | DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-(4-CARBOXY-4-{4-[(2,4-DIAMINO-PTERIDIN-6-YLMETHYL)-AMINO]-BENZOYLAMINO}-BUTYL)-PHTHALAMIC ACID, ... (4 entities in total) |
Functional Keywords | oxidoreductase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 22668.51 |
Authors | Cody, V.,Galitsky, N.,Luft, J.R.,Pangborn, W. (deposition date: 1997-09-17, release date: 1998-04-29, Last modification date: 2024-02-14) |
Primary citation | Cody, V.,Galitsky, N.,Luft, J.R.,Pangborn, W.,Rosowsky, A.,Blakley, R.L. Comparison of two independent crystal structures of human dihydrofolate reductase ternary complexes reduced with nicotinamide adenine dinucleotide phosphate and the very tight-binding inhibitor PT523. Biochemistry, 36:13897-13903, 1997 Cited by PubMed: 9374868DOI: 10.1021/bi971711l PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
Download full validation report