1OFC

nucleosome recognition module of ISWI ATPase

1OFC の概要

• エントリーDOI: 10.2210/pdb1ofc/pdb
• 分子名称: ISWI PROTEIN, alpha-D-glucopyranose, 4-deoxy-alpha-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: nuclear protein, chromatin remodeling factor, iswi, atpase, sant domain, nucleosome recognition
• 由来する生物種: DROSOPHILA MELANOGASTER (FRUIT FLY)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36322.18

構造登録者

Grune, T.,Muller, C.W. (登録日: 2003-04-10, 公開日: 2003-09-05, 最終更新日: 2024-05-08)

主引用文献

Grune, T.,Brzeski, J.,Eberharter, A.,Clapier, C.R.,Corona, D.F.V.,Becker, P.B.,Muller, C.W.
Crystal Structure and Functional Analysis of a Nucleosome Recognition Module of the Remodeling Factor Iswi
Mol.Cell, 12:449-, 2003

PubMed Abstract: Energy-dependent nucleosome remodeling emerges as a key process endowing chromatin with dynamic properties. However, the principles by which remodeling ATPases interact with their nucleosome substrate to alter histone-DNA interactions are only poorly understood. We have identified a substrate recognition domain in the C-terminal half of the remodeling ATPase ISWI and determined its structure by X-ray crystallography. The structure comprises three domains, a four-helix domain with a novel fold and two alpha-helical domains related to the modules of c-Myb, SANT and SLIDE, which are linked by a long helix. An integrated structural and functional analysis of these domains provides insight into how ISWI interacts with the nucleosomal substrate.

PubMed: 14536084
DOI: 10.1016/S1097-2765(03)00273-9

実験手法

X-RAY DIFFRACTION (1.9 Å)