1OBP

ODORANT-BINDING PROTEIN FROM BOVINE NASAL MUCOSA

1OBP の概要

• エントリーDOI: 10.2210/pdb1obp/pdb
• 分子名称: ODORANT-BINDING PROTEIN, UNKNOWN ATOM OR ION (3 entities in total)
• 機能のキーワード: olfaction, nose, transport, lipocalin, odorant-binding protein
• 由来する生物種: Bos taurus (cattle)
• 細胞内の位置: Secreted: P07435
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 36914.61

構造登録者

Tegoni, M.,Cambillau, C. (登録日: 1996-01-14, 公開日: 1996-10-14, 最終更新日: 2024-02-14)

主引用文献

Tegoni, M.,Ramoni, R.,Bignetti, E.,Spinelli, S.,Cambillau, C.
Domain swapping creates a third putative combining site in bovine odorant binding protein dimer
Nat.Struct.Biol., 3:863-867, 1996

PubMed Abstract: In mammals, odorant binding proteins may play an important role in the transport of odors towards specific olfactory receptors on sensory neurones across the aqueous compartment of the nasal mucus. We have solved the X-ray structure of such a transport protein, bovine odorant binding protein (OBP) at 2.0 A resolution. The beta-barrel of OBP is similar to that of lipocalins, but OBP dimer association results from domain swapping, an observation unique among the lipocalins. The alpha-helix of each monomer stacks against the beta-barrel of the other monomer. Contrary to previous reports, each monomer has an internal buried cavity which could accommodate a naturally occurring molecule. Besides this cavity, an open cavity is located at the dimer interface. Data in solution suggest that this central cavity may be a binding site created by domain swapping.

PubMed: 8836103
DOI: 10.1038/nsb1096-863

実験手法

X-RAY DIFFRACTION (2 Å)