1O9K

Crystal structure of the retinoblastoma tumour suppressor protein bound to E2F peptide

Summary for 1O9K

Related1PJM 1N4M 1H24 1AD6 1H25 1GH6 1GUX 2AZE
DescriptorRETINOBLASTOMA-ASSOCIATED PROTEIN, TRANSCRIPTION FACTOR E2F1, ... (4 entities in total)
Functional Keywordsapoptosis, tumour suppressor, cell cycle regulation, dna-binding
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationNucleus P06400 P06400 Q01094
Total number of polymer chains12
Total molecular weight181974.62
Authors
Xiao, B.,Spencer, J.,Clements, A.,Ali-Khan, N.,Mittnacht, S.,Broceno, C.,Burghammer, M.,Perrakis, A.,Marmorstein, R.,Gamblin, S.J. (deposition date: 2002-12-16, release date: 2003-03-06, Last modification date: 2011-07-13)
Primary citation
Xiao, B.,Spencer, J.,Clements, A.,Ali-Khan, N.,Mittnacht, S.,Broceno, C.,Burghammer, M.,Perrakis, A.,Marmorstein, R.,Gamblin, S.J.
Crystal Structure of the Retinoblastoma Tumor Suppressor Protein Bound to E2F and the Molecular Basis of its Regulation
Proc.Natl.Acad.Sci.USA, 100:2363-, 2003
PubMed: 12598654 (PDB entries with the same primary citation)
DOI: 10.1073/PNAS.0436813100
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.6 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers252.5%9.3%7.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution