1O4C

CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH PHOSPHATE.

1O4C の概要

• エントリーDOI: 10.2210/pdb1o4c/pdb
• 分子名称: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, PHOSPHATE ION (3 entities in total)
• 機能のキーワード: sh2 domain fragment approach, signaling protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane: P12931
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 12485.93

構造登録者

Lange, G.,Loenze, P.,Liesum, A. (登録日: 2003-06-15, 公開日: 2004-02-17, 最終更新日: 2023-11-15)

• 主引用文献: Lange, G.,Lesuisse, D.,Deprez, P.,Schoot, B.,Loenze, P.,Benard, D.,Marquette, J.P.,Broto, P.,Sarubbi, E.,Mandine, E.; Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.; J.Med.Chem., 46:5184-5195, 2003; PubMed: 14613321; DOI: 10.1021/jm020970s

実験手法

X-RAY DIFFRACTION (1.8 Å)