1NWL

Crystal structure of the PTP1B complexed with SP7343-SP7964, a pTyr mimetic

Summary for 1NWL

Entry DOI	10.2210/pdb1nwl/pdb
Descriptor	protein-tyrosine phosphatase, non-receptor type 1, MAGNESIUM ION, 3-(4-{2-[2-(2-BROMO-ACETYLAMINO)-ETHYLDISULFANYL]-ETHYLCARBAMOYL}-CYCLOHEXYLCARBAMOYL)-PYRAZINE-2-CARBOXYLIC ACID, ... (4 entities in total)
Functional Keywords	protein-small molecule inhibitor complex, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031
Total number of polymer chains	1
Total formula weight	35140.32
Authors	Erlanson, D.A.,McDowell, R.S.,He, M.M.,Randal, M.,Simmons, R.L.,Kung, J.,Waight, A.,Hansen, S. (deposition date: 2003-02-06, release date: 2003-04-01, Last modification date: 2024-02-14)
Primary citation	Erlanson, D.A.,McDowell, R.S.,He, M.M.,Randal, M.,Simmons, R.L.,Kung, J.,Waight, A.,Hansen, S. Discovery of a New Phosphotyrosine Mimetic for PTP1B Using Breakaway Tethering J.Am.Chem.Soc., 125:5602-5603, 2003 Cited by PubMed: 12733877 DOI: 10.1021/ja034440c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation