1NWL

Crystal structure of the PTP1B complexed with SP7343-SP7964, a pTyr mimetic

1NWL の概要

• エントリーDOI: 10.2210/pdb1nwl/pdb
• 分子名称: protein-tyrosine phosphatase, non-receptor type 1, MAGNESIUM ION, 3-(4-{2-[2-(2-BROMO-ACETYLAMINO)-ETHYLDISULFANYL]-ETHYLCARBAMOYL}-CYCLOHEXYLCARBAMOYL)-PYRAZINE-2-CARBOXYLIC ACID, ... (4 entities in total)
• 機能のキーワード: protein-small molecule inhibitor complex, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35140.32

構造登録者

Erlanson, D.A.,McDowell, R.S.,He, M.M.,Randal, M.,Simmons, R.L.,Kung, J.,Waight, A.,Hansen, S. (登録日: 2003-02-06, 公開日: 2003-04-01, 最終更新日: 2024-02-14)

• 主引用文献: Erlanson, D.A.,McDowell, R.S.,He, M.M.,Randal, M.,Simmons, R.L.,Kung, J.,Waight, A.,Hansen, S.; Discovery of a New Phosphotyrosine Mimetic for PTP1B Using Breakaway Tethering; J.Am.Chem.Soc., 125:5602-5603, 2003; PubMed: 12733877; DOI: 10.1021/ja034440c

実験手法

X-RAY DIFFRACTION (2.4 Å)