1NQ9

Crystal Structure of Antithrombin in the Pentasaccharide-Bound Intermediate State

1NQ9 の概要

• エントリーDOI: 10.2210/pdb1nq9/pdb
• 関連するPDBエントリー: 1E03 1E04 1E05 1OYH
• 関連するBIRD辞書のPRD_ID: PRD_900031
• 分子名称: Antithrombin-III, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3,4-di-O-methyl-2,6-di-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-beta-D-glucopyranuronic acid-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-3-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2,3,6-tri-O-sulfo-alpha-D-glucopyranoside, ... (5 entities in total)
• 機能のキーワード: thrombin; inhibition; heparin analogue; serine protease inhibitor, blood clotting
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted, extracellular space: P01008
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 103240.48

構造登録者

Huntington, J.A.,Johnson, D.J.D. (登録日: 2003-01-21, 公開日: 2003-09-30, 最終更新日: 2024-03-13)

• 主引用文献: Johnson, D.J.D.,Huntington, J.A.; Crystal Structure of Antithrombin in a Heparin-Bound Intermediate State; Biochemistry, 42:8712-8719, 2003; PubMed: 12873131; DOI: 10.1021/bi034524y

実験手法

X-RAY DIFFRACTION (2.6 Å)