1NQ1

TR Receptor Mutations Conferring Hormone Resistance and Reduced Corepressor Release Exhibit Decreased Stability in the Nterminal LBD

1NQ1 の概要

• エントリーDOI: 10.2210/pdb1nq1/pdb
• 分子名称: Thyroid hormone receptor beta-1, [4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID, ARSENIC (3 entities in total)
• 機能のキーワード: alpha helical, ligand binding domain, hormone-growth factor receptor complex, hormone/growth factor receptor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: P10828
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30413.03

構造登録者

Huber, B.R.,Desclozeaux, M.,West, B.L.,Cunha-Lima, S.T.,Nguyen, H.T.,Baxter, J.D.,Ingraham, H.A.,Fletterick, R.J. (登録日: 2003-01-20, 公開日: 2003-04-15, 最終更新日: 2024-04-03)

• 主引用文献: Huber, B.R.,Desclozeaux, M.,West, B.L.,Cunha-Lima, S.T.,Nguyen, H.T.,Baxter, J.D.,Ingraham, H.A.,Fletterick, R.J.; Thyroid hormone receptor-beta mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the N-terminal ligand-binding domain; Mol.Endocrinol., 17:107-116, 2003; PubMed: 12511610; DOI: 10.1210/me.2002-0097

実験手法

X-RAY DIFFRACTION (2.9 Å)